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The continuous replacement of neurons in the olfactory epithelium provides an advantageous model for investigating neuronal differentiation and maturation. The control of gene expression by chromatin modification and transcription factors, and neurite growth, protein transport, RNA processing, cholesterol biosynthesis, and apoptosis via death domain receptors, were overrepresented biological processes in immature OSNs. Ion transport ion channels , presynaptic functions, and cilia-specific processes were overrepresented in mature OSNs. Processes overrepresented among the genes expressed by all OSNs were protein and ion transport, ER overload response, protein catabolism, and the electron transport chain.
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Genomics of Mature and Immature Olfactory Sensory Neurons

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Deep sequencing of microRNA precursors reveals extensive 3′ end modification

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Deep sequencing of microRNA precursors reveals extensive 3′ end modification

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